Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

A greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies. The mechanisms of cisplatin hypersensitivity and resistance in embryonal carcinoma (EC), the st...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Singh, Ratnakar, Fazal, Zeeshan, Corbet, Andrea K., Bikorimana, Emmanuel, Rodriguez, Jennifer C., Khan, Ema M., Shahid, Khadeeja, Freemantle, Sarah J., Spinella, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627640/
https://ncbi.nlm.nih.gov/pubmed/31181810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060796
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