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Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

A greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies. The mechanisms of cisplatin hypersensitivity and resistance in embryonal carcinoma (EC), the st...

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Detalles Bibliográficos
Publicado en:Cancers (Basel)
Main Authors: Singh, Ratnakar, Fazal, Zeeshan, Corbet, Andrea K., Bikorimana, Emmanuel, Rodriguez, Jennifer C., Khan, Ema M., Shahid, Khadeeja, Freemantle, Sarah J., Spinella, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627640/
https://ncbi.nlm.nih.gov/pubmed/31181810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060796
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