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Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity

It remains largely unclear how stem cells regulate bioenergetics and genome integrity to ensure tissue homeostasis. Here, our integrative gene analyses suggest that metabolic and genotoxic stresses may underlie the common functional defects of both fetal and adult hematopoietic stem and progenitor c...

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Pubblicato in:Stem Cell Reports
Autori principali: Yang, Zhenhua, Shah, Kushani, Khodadadi-Jamayran, Alireza, Jiang, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627005/
https://ncbi.nlm.nih.gov/pubmed/31231026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.05.023
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