mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells

In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved. Here, we demonstrate that mouse bone marrow-derived TORC2-de...

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Publicat a:Front Immunol
Autors principals: Watson, Alicia R., Dai, Helong, Zheng, Yawen, Nakano, Ryosuke, Giannou, Anastasios D., Menk, Ashley V., Stolz, Donna B., Delgoffe, Greg M., Thomson, Angus W.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626913/
https://ncbi.nlm.nih.gov/pubmed/31338091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01451
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