Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8(+) effector T cell responses

Dendritic cells (DC) play a pivotal role in the induction and regulation of immune responses. In cancer, DC-based vaccines have proven to be safe and to elicit protective and therapeutic immunological responses. Recently, we showed that specific mTORC2 (mechanistic target of rapamycin complex 2) def...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Autores principales: Raïch-Regué, Dàlia, Fabian, Kellsye P., Watson, Alicia R., Fecek, Ronald J., Storkus, Walter J., Thomson, Angus W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938309/
https://ncbi.nlm.nih.gov/pubmed/27471613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1146841
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