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Synthesis of α-CF(3)-proline derivatives by means of a formal (3 + 2)-cyclisation between trifluoropyruvate imines and Michael acceptors
We herein report the first formal (3 + 2)-cyclisation between 3,3,3-trifluoropyruvate-derived imines and indandione-based Michael acceptors. This reaction gives access to a novel class of spirocyclic α-CF(3)-α-proline derivatives with complete control of the diastereoselectivity under phase transfer...
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| Publié dans: | Org Biomol Chem |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6625964/ https://ncbi.nlm.nih.gov/pubmed/31149695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ob01134j |
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