Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

Telomeres are essential for genome stability. Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere shortening. Although telomeres are hypersensitive to ROS-mediated 8-oxoguanine (8-oxoG) formation, the biological effect of this common lesion at telomeres is poorly und...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Fouquerel, Elise, Barnes, Ryan P., Uttam, Shikhar, Watkins, Simon C., Bruchez, Marcel P., Opresko, Patricia L.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625854/
https://ncbi.nlm.nih.gov/pubmed/31101499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.04.024
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