Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock

BACKGROUND: This study is to explore the effect of SIRT1 deacetylating inactivation on organ-derived high mobility group box 1 (HMGB1) during the development of severe hemorrhagic shock (HS). METHODS: Hemorrhagic shock model was reproduced in rats by blood shedding and mimicked in HK-2 cells by hypo...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Xu, Siqi, Zeng, Zhenhua, Zhao, Ming, Huang, Qiaobing, Gao, Youguang, Dai, Xingui, Lu, Jiayin, Huang, Weiqing, Zhao, Keseng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625367/
https://ncbi.nlm.nih.gov/pubmed/31333497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00854
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