Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

Pharmacologic agents that modulate ubiquitin ligase activity to induce protein degradation are a major new class of therapeutic agents, active in a number of hematologic malignancies. However, we currently have a limited understanding of the determinants of activity of these agents and how resistanc...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Sperling, Adam S., Burgess, Michael, Keshishian, Hasmik, Gasser, Jessica A., Bhatt, Shruti, Jan, Max, Słabicki, Mikołaj, Sellar, Rob S., Fink, Emma C., Miller, Peter G., Liddicoat, Brian J., Sievers, Quinlan L., Sharma, Rohan, Adams, Dylan N., Olesinski, Elyse A., Fulciniti, Mariateresa, Udeshi, Namrata D., Kuhn, Eric, Letai, Anthony, Munshi, Nikhil C., Carr, Steven A., Ebert, Benjamin L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2019
Gaiak:
Lymphoid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624968/
https://ncbi.nlm.nih.gov/pubmed/31043423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000789
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