Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability

Rubinstein-Taybi syndrome (RSTS) is an inheritable disease associated with mutations in the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP) and characterized by growth impairment, learning disabilities, and distinctive facial and skeletal features. Studies in mou...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Valor, Luis M., Pulopulos, Matias M., Jimenez-Minchan, Maria, Olivares, Roman, Lutz, Beat, Barco, Angel
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623752/
https://ncbi.nlm.nih.gov/pubmed/21289174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4737-10.2011
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