Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A(2)β Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes

Infantile neuroaxonal dystrophy (INAD) is a fatal neurodegenerative disease characterized by the widespread presence of axonal swellings (spheroids) in the CNS and PNS and is caused by gene abnormality in PLA2G6 [calcium-independent phospholipase A(2)β (iPLA(2)β)], which is essential for remodeling...

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Udgivet i:J Neurosci
Main Authors: Beck, Goichi, Sugiura, Yuki, Shinzawa, Koei, Kato, Shinsuke, Setou, Mitsutoshi, Tsujimoto, Yoshihide, Sakoda, Saburo, Sumi-Akamaru, Hisae
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623367/
https://ncbi.nlm.nih.gov/pubmed/21813701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0345-11.2011
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