Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1

Mutations in PLA2G6 have been proposed to be the cause of neurodegeneration with brain iron accumulation type 2. The present study aimed to clarify the mechanism underlying brain iron accumulation during the deficiency of calcium-independent phospholipase A2 beta (iPLA(2)β), which is encoded by the...

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Foilsithe in:PLoS One
Main Authors: Beck, Goichi, Shinzawa, Koei, Hayakawa, Hideki, Baba, Kousuke, Yasuda, Toru, Sumi-Akamaru, Hisae, Tsujimoto, Yoshihide, Mochizuki, Hideki
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624760/
https://ncbi.nlm.nih.gov/pubmed/26506412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141629
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