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Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1

Mutations in PLA2G6 have been proposed to be the cause of neurodegeneration with brain iron accumulation type 2. The present study aimed to clarify the mechanism underlying brain iron accumulation during the deficiency of calcium-independent phospholipase A2 beta (iPLA(2)β), which is encoded by the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Beck, Goichi, Shinzawa, Koei, Hayakawa, Hideki, Baba, Kousuke, Yasuda, Toru, Sumi-Akamaru, Hisae, Tsujimoto, Yoshihide, Mochizuki, Hideki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624760/
https://ncbi.nlm.nih.gov/pubmed/26506412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141629
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