Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1

Mutations in PLA2G6 have been proposed to be the cause of neurodegeneration with brain iron accumulation type 2. The present study aimed to clarify the mechanism underlying brain iron accumulation during the deficiency of calcium-independent phospholipase A2 beta (iPLA(2)β), which is encoded by the...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Beck, Goichi, Shinzawa, Koei, Hayakawa, Hideki, Baba, Kousuke, Yasuda, Toru, Sumi-Akamaru, Hisae, Tsujimoto, Yoshihide, Mochizuki, Hideki
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624760/
https://ncbi.nlm.nih.gov/pubmed/26506412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141629
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