Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in astrocytes raises the question of the ability...

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Pubblicato in:J Neurosci
Autori principali: Azarias, Guillaume, Perreten, Hélène, Lengacher, Sylvain, Poburko, Damon, Demaurex, Nicolas, Magistretti, Pierre J., Chatton, Jean-Yves
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622778/
https://ncbi.nlm.nih.gov/pubmed/21389211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4378-10.2011
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