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Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in astrocytes raises the question of the ability...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Azarias, Guillaume, Perreten, Hélène, Lengacher, Sylvain, Poburko, Damon, Demaurex, Nicolas, Magistretti, Pierre J., Chatton, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622778/
https://ncbi.nlm.nih.gov/pubmed/21389211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4378-10.2011
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