ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms

BACKGROUND: We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these recep...

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Publicado en:Cell Commun Signal
Autores principales: Longo, Jody Fromm, Brosius, Stephanie N., Black, Laurel, Worley, Stuart H., Wilson, Robert C., Roth, Kevin A., Carroll, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621970/
https://ncbi.nlm.nih.gov/pubmed/31291965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0388-5
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