Combinatorial Therapy with Tamoxifen And Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades

Chemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen potently impedes xenograft growth. In vitro, tamoxifen inhibits MPNST proliferation and survival in an estrogen receptor-independent manner; these effects...

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Publicado en:J Neuropathol Exp Neurol
Autores principales: Brosius, Stephanie N., Turk, Amy N., Byer, Stephanie J., Longo, Jody Fromm, Kappes, John C., Roth, Kevin A., Carroll, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458069/
https://ncbi.nlm.nih.gov/pubmed/25289889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000126
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