Combinatorial Therapy with Tamoxifen And Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades

Chemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen potently impedes xenograft growth. In vitro, tamoxifen inhibits MPNST proliferation and survival in an estrogen receptor-independent manner; these effects...

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Detalhes bibliográficos
Publicado no:J Neuropathol Exp Neurol
Main Authors: Brosius, Stephanie N., Turk, Amy N., Byer, Stephanie J., Longo, Jody Fromm, Kappes, John C., Roth, Kevin A., Carroll, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458069/
https://ncbi.nlm.nih.gov/pubmed/25289889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000126
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