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Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

Cellular injury in AQP4-IgG seropositive neuromyelitis spectrum disorder (herein called NMO) involves AQP4-IgG binding to astrocytes, resulting in astrocyte injury by complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) mechanisms. The rapid disease progression...

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Foilsithe in:Acta Neuropathol Commun
Main Authors: Duan, Tianjiao, Smith, Alex J., Verkman, Alan S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621951/
https://ncbi.nlm.nih.gov/pubmed/31296268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0766-7
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