Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

Cellular injury in AQP4-IgG seropositive neuromyelitis spectrum disorder (herein called NMO) involves AQP4-IgG binding to astrocytes, resulting in astrocyte injury by complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) mechanisms. The rapid disease progression...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Duan, Tianjiao, Smith, Alex J., Verkman, Alan S.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621951/
https://ncbi.nlm.nih.gov/pubmed/31296268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0766-7
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