CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

BACKGROUND: Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, causing complement-dependent cytotoxicity (CDC) and downstream inflammation. Th...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Tradtrantip, Lukmanee, Duan, Tianjiao, Yeaman, Michael R., Verkman, Alan S.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408857/
https://ncbi.nlm.nih.gov/pubmed/30851734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1448-x
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