Restoration of Synaptic Plasticity and Learning in Young and Aged NCAM-Deficient Mice by Enhancing Neurotransmission Mediated by GluN2A-Containing NMDA Receptors

Neural cell adhesion molecule (NCAM) is the predominant carrier of the unusual glycan polysialic acid (PSA). Deficits in PSA and/or NCAM expression cause impairments in hippocampal long-term potentiation and depression (LTP and LTD) and are associated with schizophrenia and aging. In this study, we...

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Publicado en:J Neurosci
Main Authors: Kochlamazashvili, Gaga, Bukalo, Olena, Senkov, Oleg, Salmen, Benedikt, Gerardy-Schahn, Rita, Engel, Andreas K., Schachner, Melitta, Dityatev, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621799/
https://ncbi.nlm.nih.gov/pubmed/22396402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5103-11.2012
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