Neural Cell Adhesion Molecule-Associated Polysialic Acid Regulates Synaptic Plasticity and Learning by Restraining the Signaling through GluN2B-Containing NMDA Receptors

The neural cell adhesion molecule (NCAM) is the predominant carrier of α2,8 polysialic acid (PSA) in the mammalian brain. Abnormalities in PSA and NCAM expression are associated with schizophrenia in humans and cause deficits in hippocampal synaptic plasticity and contextual fear conditioning in mic...

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Publié dans:J Neurosci
Auteurs principaux: Kochlamazashvili, Gaga, Senkov, Oleg, Grebenyuk, Sergei, Robinson, Catrina, Xiao, Mei-Fang, Stummeyer, Katharina, Gerardy-Schahn, Rita, Engel, Andreas K., Feig, Larry, Semyanov, Alexey, Suppiramaniam, Vishnu, Schachner, Melitta, Dityatev, Alexander
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2010
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390116/
https://ncbi.nlm.nih.gov/pubmed/20237287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5806-09.2010
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