Acute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover

The attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) to the serine and threonine residues of proteins in distinct cellular compartments is increasingly recognized as an important mechanism regulating cellular function. Importantly, the O-GlcNAc modification of mitochondrial proteins has been...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Wright, JaLessa N., Benavides, Gloria A., Johnson, Michelle S., Wani, Willayat, Ouyang, Xiaosen, Zou, Luyun, Collins, Helen E., Zhang, Jianhua, Darley-Usmar, Victor, Chatham, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620580/
https://ncbi.nlm.nih.gov/pubmed/30865517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00491.2018
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