GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma

No curative treatment options are available for advanced hepatocellular carcinoma (HCC). Anti‐PD1 antibody therapy can induce tumor regression in 20% of advanced HCC patients, demonstrating that co‐inhibitory immune checkpoint blockade has therapeutic potential for this type of cancer. However, whet...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: van Beek, Adriaan A., Zhou, Guoying, Doukas, Michail, Boor, Patrick P.C., Noordam, Lisanne, Mancham, Shanta, Campos Carrascosa, Lucia, van der Heide‐Mulder, Marieke, Polak, Wojciech G., Ijzermans, Jan N.M., Pan, Qiuwei, Heirman, Carlo, Mahne, Ashley, Bucktrout, Samantha L., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Tumor Immunology and Microenvironment
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619339/
https://ncbi.nlm.nih.gov/pubmed/30719701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32181
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