Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra-tumoral T-cells in mismatch repair-proficient li...

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Bibliografski detalji
Izdano u:Oncoimmunology
Glavni autori: Zhou, Guoying, Noordam, Lisanne, Sprengers, Dave, Doukas, Michail, Boor, Patrick P. C., van Beek, Adriaan A., Erkens, Remco, Mancham, Shanta, Grünhagen, Dirk, Menon, Anand G., Lange, Johan F., Burger, Pim J. W. A., Brandt, Alexandra, Galjart, Boris, Verhoef, Cornelis, Kwekkeboom, Jaap, Bruno, Marco J.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993483/
https://ncbi.nlm.nih.gov/pubmed/29900067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1448332
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