Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra-tumoral T-cells in mismatch repair-proficient li...

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Опубликовано в: :Oncoimmunology
Главные авторы: Zhou, Guoying, Noordam, Lisanne, Sprengers, Dave, Doukas, Michail, Boor, Patrick P. C., van Beek, Adriaan A., Erkens, Remco, Mancham, Shanta, Grünhagen, Dirk, Menon, Anand G., Lange, Johan F., Burger, Pim J. W. A., Brandt, Alexandra, Galjart, Boris, Verhoef, Cornelis, Kwekkeboom, Jaap, Bruno, Marco J.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2018
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993483/
https://ncbi.nlm.nih.gov/pubmed/29900067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1448332
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