Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors

CD4(+) type 1 T regulatory (Tr1) cells have a crucial role in inducing tolerance. Immune regulation by these cells is mainly mediated through the secretion of high amounts of IL-10. Several studies have suggested that this regulatory population may be involved in tumor-mediated immune-suppression. H...

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Vydáno v:Oncoimmunology
Hlavní autoři: Pedroza-Gonzalez, Alexander, Zhou, Guoying, Vargas-Mendez, Ernesto, Boor, Patrick PC, Mancham, Shanta, Verhoef, Cornelis, Polak, Wojciech G, Grünhagen, Dirk, Pan, Qiuwei, Janssen, Harry LA, Garcia-Romo, Gina S, Biermann, Katharina, Tjwa, Eric TTL, IJzermans, Jan NM, Kwekkeboom, Jaap, Sprengers, Dave
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485712/
https://ncbi.nlm.nih.gov/pubmed/26155417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1008355
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