GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo

In liver cancer tumor-infiltrating regulatory T cells (Ti-Treg) are potent suppressors of tumor-specific T-cell responses and express high levels of the Treg-associated molecules cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and glucocorticoid-induced tumor necrosis factor receptor (GITR). In...

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Publicat a:Oncoimmunology
Autors principals: Pedroza-Gonzalez, Alexander, Zhou, Guoying, Singh, Simar Pal, Boor, Patrick PC, Pan, Qiuwei, Grunhagen, Dirk, de Jonge, Jeroen, Tran, TC Khe, Verhoef, Cornelis, IJzermans, Jan NM, Janssen, Harry LA, Biermann, Katharina, Kwekkeboom, Jaap, Sprengers, Dave
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635937/
https://ncbi.nlm.nih.gov/pubmed/26587321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1051297
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