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Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

BACKGROUND: Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with diseas...

詳細記述

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書誌詳細
出版年:Mol Neurodegener
主要な著者: Bercier, Valérie, Hubbard, Jeffrey M., Fidelin, Kevin, Duroure, Karine, Auer, Thomas O., Revenu, Céline, Wyart, Claire, Del Bene, Filippo
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617949/
https://ncbi.nlm.nih.gov/pubmed/31291987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0327-3
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