Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

BACKGROUND: Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with diseas...

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Udgivet i:Mol Neurodegener
Main Authors: Bercier, Valérie, Hubbard, Jeffrey M., Fidelin, Kevin, Duroure, Karine, Auer, Thomas O., Revenu, Céline, Wyart, Claire, Del Bene, Filippo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617949/
https://ncbi.nlm.nih.gov/pubmed/31291987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0327-3
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