Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

BACKGROUND: Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with diseas...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Bercier, Valérie, Hubbard, Jeffrey M., Fidelin, Kevin, Duroure, Karine, Auer, Thomas O., Revenu, Céline, Wyart, Claire, Del Bene, Filippo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617949/
https://ncbi.nlm.nih.gov/pubmed/31291987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0327-3
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