Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Metformin is an important antidiabetic drug and often used as a probe for drug–drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism, the previously reported physiologically‐based phar...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:CPT Pharmacometrics Syst Pharmacol
Main Authors: Nishiyama, Kotaro, Toshimoto, Kota, Lee, Wooin, Ishiguro, Naoki, Bister, Bojan, Sugiyama, Yuichi
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617824/
https://ncbi.nlm.nih.gov/pubmed/30821133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12398
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