Загрузка...
Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects
PURPOSE: To establish a physiologically-based pharmacokinetic (PBPK) model for analyzing the factors associated with side effects of irinotecan by using a computer-based virtual clinical study (VCS) because many controversial associations between various genetic polymorphisms and side effects of iri...
Сохранить в:
| Опубликовано в: : | Pharm Res |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer US
2017
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5498655/ https://ncbi.nlm.nih.gov/pubmed/28397089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2153-z |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|