Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen

The Tamoxifen Response by CYP2D6 Genotype‐based Treatment‐1 (TARGET‐1) study (n = 180) was conducted from 2012–2017 in Japan to determine the efficacy of tamoxifen dosing guided by cytochrome P450 2D6 (CYP2D6) genotypes. To predict its outcomes prior to completion, we constructed the comprehensive p...

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書目詳細資料
發表在:CPT Pharmacometrics Syst Pharmacol
Main Authors: Nakamura, Toshimichi, Toshimoto, Kota, Lee, Wooin, Imamura, Chiyo K., Tanigawara, Yusuke, Sugiyama, Yuichi
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063740/
https://ncbi.nlm.nih.gov/pubmed/29920987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12307
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