Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects

PURPOSE: To establish a physiologically-based pharmacokinetic (PBPK) model for analyzing the factors associated with side effects of irinotecan by using a computer-based virtual clinical study (VCS) because many controversial associations between various genetic polymorphisms and side effects of iri...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Toshimoto, Kota, Tomaru, Atsuko, Hosokawa, Masakiyo, Sugiyama, Yuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498655/
https://ncbi.nlm.nih.gov/pubmed/28397089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2153-z
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