Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization

Hyperglycemia aggravates hepatic ischemia/reperfusion injury (IRI), but the underlying mechanism for the aggravation remains elusive. Sphingosine‐1‐phosphate (S1P) and sphingosine‐1‐phosphate receptors (S1PRs) have been implicated in metabolic and inflammatory diseases. Here, we discuss whether and...

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Veröffentlicht in:Liver Transpl
Hauptverfasser: Hu, Yuanchang, Yang, Chao, Shen, Gefengqiang, Yang, Shikun, Cheng, Xuyu, Cheng, Feng, Rao, Jianhua, Wang, Xuehao
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617772/
https://ncbi.nlm.nih.gov/pubmed/30972941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lt.25470
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