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Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors

Standard therapy for advanced Prostate Cancer (PCa) consists of antiandrogens, which provide respite from disease progression, but ultimately fail resulting in the incurable phase of the disease: mCRPC. Targeting PCa cells before their progression to mCRPC would greatly improve the outcome. Combinat...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Singh, Vibha, Jaiswal, Praveen Kumar, Ghosh, Ishita, Koul, Hari K., Yu, Xiuping, De Benedetti, Arrigo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617729/
https://ncbi.nlm.nih.gov/pubmed/30737777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32200
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