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Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity

The Tousled Like kinases (TLKs) are involved in numerous cellular functions, including the DNA Damage Response (DDR), but only a handful of substrates have been identified thus far. Through a novel proteomic screen, we have now identified 165 human proteins interacting with TLK1, and we have focused...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Singh, Vibha, Connelly, Zachary M., Shen, Xinggui, De Benedetti, Arrigo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462085/
https://ncbi.nlm.nih.gov/pubmed/28426283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1314421
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