Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression

BACKGROUND: The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency. While multiple groups ha...

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Vydáno v:BMC Dev Biol
Hlavní autoři: Reimer, Michael, Pulakanti, Kirthi, Shi, Linzheng, Abel, Alex, Liang, Mingyu, Malarkannan, Subramaniam, Rao, Sridhar
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615237/
https://ncbi.nlm.nih.gov/pubmed/31286885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12861-019-0196-6
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