Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait

Genetic variants disrupting DNA methylation at CpG dinucleotides (CpG-SNP) provide a set of known causal variants to serve as models to test fine-mapping methodology. We use 1716 CpG-SNPs to test three fine-mapping approaches (Bayesian imputation-based association mapping, Bayesian sparse linear mix...

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Vydáno v:Genetics
Hlavní autoři: Chundru, V. Kartik, Marioni, Riccardo E., Prendergast, James G. D., Vallerga, Costanza L., Lin, Tian, Beveridge, Allan J., Gratten, Jacob, Hume, David A., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2019
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614908/
https://ncbi.nlm.nih.gov/pubmed/31040117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301861
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