Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with complex traits and diseases. However, elucidating the causal genes underlying GWAS hits remains challenging. We applied the summary data-based Mendelian randomization (SMR) method to 28 GWAS summary d...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Pavlides, Jennifer M. Whitehead, Zhu, Zhihong, Gratten, Jacob, McRae, Allan F., Wray, Naomi R., Yang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979185/
https://ncbi.nlm.nih.gov/pubmed/27506385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0338-4
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