Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

To date, an effective therapeutic treatment that confers strong attenuation toward coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs is considered to be one of the most important. Here, we first present the structure of the full-length Nsp13 helicase of SA...

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Publicado en:Nucleic Acids Res
Autores principales: Jia, Zhihui, Yan, Liming, Ren, Zhilin, Wu, Lijie, Wang, Jin, Guo, Jing, Zheng, Litao, Ming, Zhenhua, Zhang, Lianqi, Lou, Zhiyong, Rao, Zihe
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614802/
https://ncbi.nlm.nih.gov/pubmed/31131400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz409
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