Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for prevention of lethal mutagenesis, and the C-terminal domain functions as a (guanine-N7) methyl transferase (N7-MTas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Ma, Yuanyuan, Wu, Lijie, Shaw, Neil, Gao, Yan, Wang, Jin, Sun, Yuna, Lou, Zhiyong, Yan, Liming, Zhang, Rongguang, Rao, Zihe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522806/
https://ncbi.nlm.nih.gov/pubmed/26159422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508686112
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