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Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds

According to recent research advance, it is interesting to identify new, potent and selective inhibitors of human butyrylcholinesterase (BChE) for therapeutic treatment of both the Alzheimer’s disease (AD) and heroin abuse. In this study, we carried out a structure-based virtual screening followed b...

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Detalhes bibliográficos
Publicado no:Chem Biol Interact
Main Authors: Zhou, Shuo, Yuan, Yaxia, Zheng, Fang, Zhan, Chang-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613991/
https://ncbi.nlm.nih.gov/pubmed/31152736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2019.05.051
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