A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy

Patients with triple-negative breast cancer (TNBC) often have a poor prognosis largely due to lack of effective targeted therapy. Using a library of seleno-purines coupled to a high-throughput biochemical enzymatic assays we identified a potent pharmacological enhancer of autophagy (referred herein...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Chang, Chia-Hao, Bijian, Krikor, Wernic, Dominik, Su, Jie, da Silva, Sabrina Daniela, Yu, Henry, Qiu, Dinghong, Asslan, Mariana, Alaoui-Jamali, Moulay A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613893/
https://ncbi.nlm.nih.gov/pubmed/30773992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1582951
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