Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3′-Terminal Adenylyltransferase Activity

Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and found that the protein has metal ion-dependent RNA 3...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Tvarogová, Jana, Madhugiri, Ramakanth, Bylapudi, Ganesh, Ferguson, Lyndsey J., Karl, Nadja, Ziebuhr, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613758/
https://ncbi.nlm.nih.gov/pubmed/30918070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00291-19
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