Human Coronavirus 229E Papain-Like Proteases Have Overlapping Specificities but Distinct Functions in Viral Replication

Expression of the exceptionally large RNA genomes of CoVs involves multiple regulatory mechanisms, including extensive proteolytic processing of the large replicase polyproteins, pp1a and pp1ab, by two types of cysteine proteases: the chymotrypsin-like main protease and papain-like accessory proteas...

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Detalhes bibliográficos
Main Authors: Ziebuhr, John, Schelle, Barbara, Karl, Nadja, Minskaia, Ekaterina, Bayer, Sonja, Siddell, Stuart G., Gorbalenya, Alexander E., Thiel, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866161/
https://ncbi.nlm.nih.gov/pubmed/17251282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02091-06
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