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Substrate-differentiated Transition States of SET7/9-catalyzed Lysine Methylation
Transition state stabilization is essential for rate acceleration of enzymatic reactions. Despite extensive studies on various transition state structures of enzymes, an intriguing puzzle is whether an enzyme can accommodate multiple transition states (TS) to catalyze a chemical reaction. It is expe...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6613214/ https://ncbi.nlm.nih.gov/pubmed/31034218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b02553 |
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