Substrate-differentiated Transition States of SET7/9-catalyzed Lysine Methylation

Transition state stabilization is essential for rate acceleration of enzymatic reactions. Despite extensive studies on various transition state structures of enzymes, an intriguing puzzle is whether an enzyme can accommodate multiple transition states (TS) to catalyze a chemical reaction. It is expe...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Chen, Shi, Kapilashrami, Kanishk, Senevirathne, Chamara, Wang, Zhen, Wang, Junyi, Linscott, Joshua A., Luo, Minkui
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613214/
https://ncbi.nlm.nih.gov/pubmed/31034218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b02553
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