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Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8
Protein lysine methyltransferases (PKMTs) catalyze the methylation of protein substrates, and their dysregulation has been linked to many diseases, including cancer. Accumulated evidence suggests that the reaction path of PKMT-catalyzed methylation consists of the formation of a cofactor(cosubstrate...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206543/ https://ncbi.nlm.nih.gov/pubmed/27940912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609032114 |
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