PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether glycolytic regulator 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3)-mediated endothelial glycolysis plays a critical role in the develo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cao, Yapeng, Zhang, Xiaoyu, Wang, Lina, Yang, Qiuhua, Ma, Qian, Xu, Jiean, Wang, Jingjing, Kovacs, Laszlo, Ayon, Ramon J., Liu, Zhiping, Zhang, Min, Zhou, Yaqi, Zeng, Xianqiu, Xu, Yiming, Wang, Yong, Fulton, David J., Weintraub, Neal L., Lucas, Rudolf, Dong, Zheng, Yuan, Jason X.-J., Sullivan, Jennifer C., Meadows, Louise, Barman, Scott A., Wu, Chaodong, Quan, Junmin, Hong, Mei, Su, Yunchao, Huo, Yuqing
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613097/
https://ncbi.nlm.nih.gov/pubmed/31213542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821401116
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