PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has been hypothesized to drive increased inflammation and lesion burden but direct links remain to be established. Here we show that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increa...

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Publicado no:Nat Commun
Main Authors: Yang, Qiuhua, Xu, Jiean, Ma, Qian, Liu, Zhiping, Sudhahar, Varadarajan, Cao, Yapeng, Wang, Lina, Zeng, Xianqiu, Zhou, Yaqi, Zhang, Min, Xu, Yiming, Wang, Yong, Weintraub, Neal L., Zhang, Chunxiang, Fukai, Tohru, Wu, Chaodong, Huang, Lei, Han, Zhen, Wang, Tao, Fulton, David J., Hong, Mei, Huo, Yuqing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220207/
https://ncbi.nlm.nih.gov/pubmed/30405100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07132-x
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